Ich habe mal nach Studien gesucht zum Thema Impfung Transplantiert Immunantwort
Um grosse Studien zu machen, war die Zeit noch zu kurz. Aber erste kleinere Studien gibt es schon. Weitere werden folgen...
Reaktion von fast 200 Organtransplantierten auf die 1. Impfung gegen SARS-CoV-2 - datiert 5.2.2021
Quelle: Johns Hopkins University School of Medicine
STUDY INDICATES COVID-19 VACCINES ARE SAFE FOR ORGAN TRANSPLANT PATIENTS
Media Contact: Michael E. Newman,
In what may be the first study of its kind, Johns Hopkins Medicine researchers have documented the reaction of nearly 200 solid organ transplant recipients to their first vaccine inoculation against SARS-CoV-2, the virus that causes COVID-19. The findings, they say, provide evidence that both the Moderna and Pfizer/BioNTech messenger RNA (mRNA) vaccines can be safely given to this immunocompromised population.
The study was posted online Feb. 5, 2021, in the journal Transplantation.
To better understand the safety of the SARS-CoV-2 mRNA vaccines for transplant patients, the researchers studied 187 transplant recipients who received an initial dose of either the Moderna or Pfizer/BioNTech vaccines between Dec. 16, 2020and Jan. 16, 2021. The study participants were recruited by invitation through their transplant centers or social media.
Fifty-two percent (97) were kidney transplant recipients; 19% (35) were liver; 14% (26) were heart; 9% (17) were lung; 3% (six) were kidney and pancreas; and (six) were other multi-organ recipients. The median age was 48; 69% (129) were female, 87% (163) were white; and 6% (11) were Hispanic or Latino. Vaccinations occurred at a median of six years following transplant surgery. All were receiving immunosuppression medications to prevent rejection of their transplanted organs.
Between the time of their vaccination and study participation (which consisted of completing a detailed questionnaire one week after they received the vaccine), there were no diagnoses of SARS-CoV-2 infections.
Few of the transplant recipients in the study had systemic adverse reactions, such as fever (seven, or 4%) and chills (17, or 9%), to the Moderna and Pfizer/BioNTech vaccines -- statistics that were similar to those seen for participants in the large, randomized clinical trials that validated the safety of the two prophylactic treatments. The majority of the transplant recipients reported local reactions, including mild pain at the site of inoculation (114, or 61%), mild redness (13, or 7%) and mild swelling (30, or 16%).
Additionally, the researchers say, organ rejection -- a common concern about vaccinating transplant recipients -- did not occur.
"We hope to further this research by exploring any unexpected safety issues with long-term follow-up studies of these patients in the future," says Jacqueline Garonzik Wang, M.D., Ph.D., associate professor of surgery at the Johns Hopkins University School of Medicine and study senior author.
"These insights are critical toward protecting the lives and quelling the fears of transplant recipients who might be hesitant about getting the SARS-CoV-2 vaccines," says study co-author Dorry Segev, M.D., Ph.D., the Marjory K. and Thomas Pozefsky Professor of Surgery and Epidemiology and director of the Epidemiology Research Group in Organ Transplantation at the Johns Hopkins University School of Medicine.
Garonzik Wang and Segev are available for interviews.
Eine andere Studie zum Thema
"Transplantierte können trotz Immunsuppression eine Immunität entwickeln nach dem Durchmachen einer COVID-19-Infektion" datiert 19.2.2021
Quelle: Johns Hopkins University School of Medicine
ORGAN TRANSPLANT RECIPIENTS CAN DEVELOP IMMUNITY AFTER COVID-19, DESPITE IMMUNOSUPPRESSION
Media Contact: Michael E. Newman,
Johns Hopkins Medicine researchers have shown that it is possible for solid organ transplant recipients who contract COVID-19 to experience a natural immune response to SARS-CoV-2, the virus that causes the disease. In their study, published online Jan. 19, 2021, in the journal Transplantation, the researchers also suggest that measures used to provide short-term immunity against SARS-CoV-2 -- such as convalescent plasma (which contains antibodies from patients who have recovered from COVID-19) -- may actually reduce the natural response.
"We followed 18 transplant recipients who were taking immunosuppressive medications to prevent rejection and who developed COVID-19 post-transplant," says study co-author Dorry Segev, M.D., Ph.D., the Marjory K. and Thomas Pozefsky Professor of Surgery and Epidemiology and director of the Epidemiology Research Group in Organ Transplantation at the Johns Hopkins University School of Medicine. "Our goal was to gain a deeper understanding of the immune response in these individuals, so that clinicians will be better able to treat transplant recipients who get COVID-19, prevent their disease from becoming severe and develop vaccine protocols that fit their special needs."
The study participants, all of whom were receiving immunosuppressive medication, represented a variety of organ transplants: nine kidney, five liver, one kidney and liver, two lung and one composite tissue allograft (composed of different tissue types, such as skin, muscle, bone, bone marrow, lymph nodes, nerves and tendons). The median age was 56, 56% (10) were female, 33% (six) were Black and 11% (two) were Hispanic. COVID-19 occurred at a median of six years following transplant surgery, with 89% (16) experiencing symptoms and 72% (13) requiring hospitalization. Five patients received convalescent plasma during their hospital stay. When the participants were screened for SARS-CoV-2 antibodies at a median 98 days after COVID-19 diagnosis, the researchers observed that most had antibody levels suggesting neutralizing immunity -- the ability to prevent reinfection if exposed to the virus in the future.
Transplant recipients who had more severe cases of COVID-19, the researchers say, tended to have the highest antibody levels.
Interestingly, the researchers found that transplant recipients who received convalescent plasma or intravenous immunoglobulin (to reduce the risk of a serious inflammatory response) had lower natural antibody levels against the virus and, therefore, were less likely to have immunity.
"This raises the possibility that administered antibody preparations may blunt the natural formation of antibodies against SARS-CoV-2," says Jacqueline Garonzik Wang, M.D., Ph.D., associate professor of surgery at the Johns Hopkins University School of Medicine and study senior author. "Larger studies will be needed to substantiate this finding, which, if proven, would be invaluable to COVID-19 vaccine protocol development for the immunocompromised."
Segev and Garonzik Wang are available for interviews.
Diverse europäische Universitätsspitäler "stecken" hinter dieser Studie (datiert 8.2.2021), in der auch Dialysepatienten erwähnt werden. Zusammengefasst: zukünftige Forschung wird zeigen, wie erfolgreich die Impfung ist.
Ganzer Text hier
Ich habe nur den die Dialyse betreffenden Teil kopiert.
Patients receiving chronic dialysis
Dialysis units are particularly high-risk locations for infection with SARS-CoV-2. Seroconversion after confirmed infection approaches 100% in the dialysis population, but the durability of this immune response and the extent to which it translates into protective immunity remains unclear. Some studies indicate that SARS-CoV-2 IgG titres decline substantially by 3 months after diagnosis8. Thus, it is critical that as dialysis units begin to vaccinate their patients, post-vaccination antibody levels are monitored to determine optimal immunization schedules. Moreover, ongoing research should elucidate whether particular vaccines offer specific advantages for people on chronic dialysis.
